The endocrine-disrupting effect and other physiological responses of municipal effluent on the clam Ruditapes decussatus.
Identifieur interne : 000153 ( Main/Exploration ); précédent : 000152; suivant : 000154The endocrine-disrupting effect and other physiological responses of municipal effluent on the clam Ruditapes decussatus.
Auteurs : Sawssan Mezghani-Chaari [Tunisie] ; Monia Machreki-Ajmi [Tunisie] ; Gauthier Tremolet [France] ; Kristell Kellner [France] ; Alain Geffard [France] ; Christophe Minier [France] ; Amel Hamza-Chaffai [Tunisie]Source :
- Environmental science and pollution research international [ 1614-7499 ] ; 2015.
Descripteurs français
- Wicri :
- geographic : Tunisie.
English descriptors
- KwdEn :
- Animals, Bivalvia (drug effects), Bivalvia (metabolism), Endocrine Disruptors (analysis), Endocrine Disruptors (toxicity), Gills (metabolism), Male, Malondialdehyde (analysis), Metals, Heavy (analysis), Oxidative Stress, Reproduction (drug effects), Tunisia, Vitellogenins (analysis), Waste Water (chemistry), Water Pollutants, Chemical (analysis), Water Pollutants, Chemical (toxicity).
- MESH :
- chemical , analysis : Endocrine Disruptors, Malondialdehyde, Metals, Heavy, Vitellogenins, Water Pollutants, Chemical.
- chemical , chemistry : Waste Water.
- chemical , toxicity : Water Pollutants, Chemical.
- geographic : Tunisia.
- drug effects : Bivalvia, Reproduction.
- metabolism : Bivalvia, Gills.
- chemical , toxicity : Endocrine Disruptors.
- Animals, Male, Oxidative Stress.
Abstract
In order to document the potential endocrine disrupting and toxic effect of the municipal wastewater effluents discharged into the Sfax coastal area (South of Tunisia), specimens of clam R. decussatus were collected from a reference site and were in vivo exposed to treated sewage effluent for 30 days. To this end, estrogenic and androgenic activities were measured in the gills to assess potential accumulation and regulation of active compounds. After effluent exposure androgenic activity in organic extracts increased up to fivefold compared to controls and remained elevated, while estrogenic activity was not significantly affected by exposure. As a consequence, remarkable disruptions in the gametogenesis activity, glycogen content, and Vitellogenin-like protein levels in male clams were observed. A parallel analysis of heavy metals in clam tissues was determined. A significant uptake of Ni, Zn, and Pb in soft tissues of exposed clams was observed. The significant increase of malondialdehyde (MDA) concentrations as a function of exposure time implies that clams have been exposed to an oxidative stress probably due to the presence of high metal concentrations in sewage effluent. Correlation analysis has revealed a statistically significant and positive relationship between MDA levels and metal concentrations in clams' tissues. The acetylcholinesterase activity was not significantly affected by exposure. Altogether, these results showed that a short-term exposure to a mixture of chemical compounds released by the Sfax wastewater treatment plant induce adverse physiological and reproductive effects in R. decussatus. Further studies are underway in order to evaluate its long-term impacts on aquatic wildlife in the gulf of Gabes area.
DOI: 10.1007/s11356-015-5199-7
PubMed: 26278908
Affiliations:
- France, Tunisie
- Basse-Normandie, Champagne-Ardenne, Grand Est, Haute-Normandie, Région Normandie
- Caen, Le Havre, REIMS
- Université de Caen Basse-Normandie, Université de Reims Champagne-Ardenne
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Le document en format XML
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type="chemical" qualifier="analysis" xml:lang="en"><term>Endocrine Disruptors</term><term>Malondialdehyde</term><term>Metals, Heavy</term><term>Vitellogenins</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Waste Water</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Tunisia</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bivalvia</term><term>Reproduction</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bivalvia</term><term>Gills</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Endocrine Disruptors</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Oxidative Stress</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Tunisie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In order to document the potential endocrine disrupting and toxic effect of the municipal wastewater effluents discharged into the Sfax coastal area (South of Tunisia), specimens of clam R. decussatus were collected from a reference site and were in vivo exposed to treated sewage effluent for 30 days. To this end, estrogenic and androgenic activities were measured in the gills to assess potential accumulation and regulation of active compounds. After effluent exposure androgenic activity in organic extracts increased up to fivefold compared to controls and remained elevated, while estrogenic activity was not significantly affected by exposure. As a consequence, remarkable disruptions in the gametogenesis activity, glycogen content, and Vitellogenin-like protein levels in male clams were observed. A parallel analysis of heavy metals in clam tissues was determined. A significant uptake of Ni, Zn, and Pb in soft tissues of exposed clams was observed. The significant increase of malondialdehyde (MDA) concentrations as a function of exposure time implies that clams have been exposed to an oxidative stress probably due to the presence of high metal concentrations in sewage effluent. Correlation analysis has revealed a statistically significant and positive relationship between MDA levels and metal concentrations in clams' tissues. The acetylcholinesterase activity was not significantly affected by exposure. Altogether, these results showed that a short-term exposure to a mixture of chemical compounds released by the Sfax wastewater treatment plant induce adverse physiological and reproductive effects in R. decussatus. Further studies are underway in order to evaluate its long-term impacts on aquatic wildlife in the gulf of Gabes area.</div></front></TEI><affiliations><list><country><li>France</li><li>Tunisie</li></country><region><li>Basse-Normandie</li><li>Champagne-Ardenne</li><li>Grand Est</li><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Caen</li><li>Le Havre</li><li>REIMS</li></settlement><orgName><li>Université de Caen Basse-Normandie</li><li>Université de Reims Champagne-Ardenne</li></orgName></list><tree><country name="Tunisie"><noRegion><name sortKey="Mezghani Chaari, Sawssan" sort="Mezghani Chaari, Sawssan" uniqKey="Mezghani Chaari S" first="Sawssan" last="Mezghani-Chaari">Sawssan Mezghani-Chaari</name></noRegion><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name><name sortKey="Machreki Ajmi, Monia" sort="Machreki Ajmi, Monia" uniqKey="Machreki Ajmi M" first="Monia" last="Machreki-Ajmi">Monia Machreki-Ajmi</name></country><country name="France"><region name="Région Normandie"><name sortKey="Tremolet, Gauthier" sort="Tremolet, Gauthier" uniqKey="Tremolet G" first="Gauthier" last="Tremolet">Gauthier Tremolet</name></region><name sortKey="Geffard, Alain" sort="Geffard, Alain" uniqKey="Geffard A" first="Alain" last="Geffard">Alain Geffard</name><name sortKey="Kellner, Kristell" sort="Kellner, Kristell" uniqKey="Kellner K" first="Kristell" last="Kellner">Kristell Kellner</name><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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